Senior Scientist II (Preclinical Bioanalysis)

SUMMARY/JOB PURPOSE:

The Senior Scientist II of preclinical bioanalysis provides preclinical bioanalytical support for the advancement of the biologics portfolio at Exelixis. The incumbent must have strong LCMS-based bioanalysis experience as s/he supports preclinical activities of ongoing and new projects in antibody drug conjugates and other biologics.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Independently design and execute assay development and qualification of ADCs or other biologics in rodent and NHP matrices, perform pharmacokinetic sample analyses in support of proof-of-concept studies on biologic oncology programs from discovery to lead selection.

• Design, implement and manage studies for pharmacokinetic characterization of biologic drug candidates conducted by CROs and in-house as needed.

• Critical scientific/technical data analysis and interpretation of experiments.

• Interact and collaborate with internal departments to deliver quality and timely findings in support of drug candidate advancement.

• Effectively communicate scientific concepts, findings, and interpretation to multi-disciplinary teams.

• Contribute to other translational biology efforts

• Follow company intellectual property and compliance policies and practices.

• Comply with company health and safety policies and general laboratory practices.

SUPERVISORY RESPONSIBILITIES:

• Directing work to a CRO, Consultant, or 3rd party as necessary

EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS:

Education:

*Master's degree in analytical chemistry or biology or closely related discipline and a minimum of seven (7) years of related experience; or

*PhD degree in analytical chemistry or biology or closely related discipline and a minimum of two (2) years of related experience is preferred; or

*Equivalent combination of education and experience.

Experience:

• Hand-on experience in assay development and sample analysis with LCMS-based bioanalytical assays for biologics is essential.

• Scientific understanding of in vitro and in vivo pharmacology, PK, and PD concepts in cancer biology is important.

Knowledge/Skills:

• Demonstrated drive for rigorous scientific excellence. Ability to think critically and creatively to identify and solve scientific problems.

• Knowledge and familiarity in LC-MS-based bioanalysis is critical

• Ability to work independently, good time management and organization skills.

• Knowledge and experience of ligand-binding assays and metabolite ID is a plus

• Excellent written, oral, and interpersonal communication skills.

• A strong team player.

• Advanced knowledge in Excel, Word, PowerPoint, PDF, GraphPad prism.

• Good tracking record and report writing.

WORKING CONDITIONS:

*Environment: primarily working in laboratories or in office

*Exposures encountered, such as hazardous materials, and extreme cold.

*Travel required (up to 10%)

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If you have a disability and need an accommodation in relation to the application and/or recruitment process, please email us at: recruiting@exelixis.com.

WORKING CONDITIONS:

Our office is a modern space that fosters collaboration and creativity. Teams work closely together, sharing ideas and solutions in a supportive atmosphere. We provide all necessary equipment, including dual monitors and ergonomic chairs, to ensure a comfortable workspace.

DISCLAIMER:
The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.