The Broad Institute's Cancer Program is dedicated to advancing cancer research and treatment through innovative and systematic approaches. The DepMap initiative aims to comprehensively map cancer vulnerabilities using functional genomics and other high-throughput screening methods. This effort seeks to identify optimal therapeutic targets for cancer treatment. DepMap has established the DepMap Consortium, a collaboration with leading pharmaceutical and biotech companies, to collectively build this pre-clinical resource. Additionally, DepMap is a key leader in PedDep, an initiative focused on accelerating target discovery for childhood cancers.
We are seeking a highly motivated Scientist with expertise in CRISPR-based functional genomics and a proven background in managing high-throughput laboratory operations. This individual will play a pivotal leadership role in overseeing our internal screening and profiling platform, encompassing both scientific execution and daily lab management.
In this dual role of scientific lead and operations supervisor, this individual will collaborate closely with experimental scientists, project managers, and data analysts to ensure the generation of high-quality screening data within a production-oriented environment. The successful candidate is expected to excel in a cross-functional setting.
With over a decade of experience in building large-scale datasets, this position offers significant opportunities for professional growth and learning in cancer research, therapeutic target discovery, and functional genomics within a cutting-edge environment. This is an excellent chance to contribute to transformative cancer research in a collaborative setting, with ample opportunities to engage with industry and academic leaders.
Key Responsibilities:
- Lead and manage large-scale CRISPR screens and other high-throughput screening initiatives.
- Coordinate with interdisciplinary teams to ensure the successful execution of screening projects.
- Develop and implement standard operating procedures (SOPs), including experimental design, data acquisition, and analysis.
- Provide leadership on project timelines, budgets, and resource allocation to ensure timely and successful project completion.
- Mentor and support team members to promote best practices.
- Maintain accurate records and documentation using Laboratory Information Management Systems (LIMS).
- Manage a team of 2+ research associates and collaborate with scientists to achieve project goals.
Qualifications:
- Ph.D. or equivalent experience in Cancer Biology, Molecular Biology, Biochemistry, or Genetics.
- A minimum of three years of experience conducting large-scale CRISPR screens or utilizing other high-throughput screening methodologies.
- Proficiency in laboratory automation, project management software, electronic lab notebooks (ELNs), and laboratory information management systems (LIMS).
- Familiarity with the analysis of large-scale datasets.
- Prior experience in personnel management is required.
- Exceptional organizational and project management abilities.
- Strong communication and interpersonal skills are essential, with the ability to collaborate effectively in a team-oriented environment.
- Experience managing multiple projects and adhering to established timelines.
Preferred Qualifications:
- Familiarity with cancer biology and therapeutic target identification.
- Knowledge of single-cell perturb-seq approaches
- Interested candidates should submit a cover letter, resume, and contact information for three references.
Broad Institute
Aug 12, 2025