Scientist 3, Peptide Discovery, Conjugation

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The Opportunity

We are a multidisciplinary team within the department of Peptide Therapeutics whose work spans multiple applications, including the development of peptides as drugs for different disease areas, as tissue-selective targeting ligands, or as tool molecules to study emerging biology. We also innovate on platform technologies to expand our discovery capabilities and enable ongoing portfolio research. We're looking for a bench-focused scientist that will have opportunities to contribute towards the various stages of the peptide discovery and development process, including the identification of hit molecules from library selection/screening studies, validation of synthetically made compounds using binding and functional assays, and optimization of properties through re-screening efforts, structure-based rational design, and bioconjugation.

Who You Are

• Ph.D. in chemistry, chemical biology, or a related discipline working extensively with peptides, proteins, and/or other biomolecules

• A minimum of 3 years of relevant experience, ideally in industry, in basic solution phase synthesis (including various bioconjugation techniques), purification by automated flash chromatography and/or prep-HPLC, and standard peptide analytical methods (e.g. analytical HPLC, LCMS, MALDI, etc.)

• Willingness to work with and innovate using library display technologies (phage, mRNA, yeast); previous display experience is preferred but not required

• Eagerness to learn new techniques when appropriate

• Can work both independently and collaboratively; is highly team-oriented

• Has strong analytical, organizational, and communication skills

• Record of productivity (journal articles, patents, etc.)

Preferred

• Relevant postdoc or industry experience

• Expertise in modeling peptide-protein interactions using appropriate software (MOE or Schrodinger)

• Experience with standard protein analytical methods (LCMS, SDS-PAGE, SEC, western)

• Experience with biochemical (e.g. ELISA), biophysical (e.g. SPR/BLI/FP), and cell-based assays

• Experience with protein expression and purification (affinity, ion exchange, size exclusion, and/or HPLC)

• previous display experience is preferred but not required

Relocation benefits are available for this posting.

The expected salary range for this position based on the primary location of California is $101,400 - $188,200. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

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Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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