Bioinformatics Analyst I-II

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world's leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world's deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems.

The Bioinformatics Analyst I-II will provide data analysis services to researchers in the Dhodapkar lab, particularly focusing on single cell genomics, integration of high-dimensional immunologic data and genome sequencing. This position requires the ability to work independently, manage multiple overlapping demands, and communicate effectively with faculty, post-doctoral fellows, and research staff on a wide range of topics in biology, analytical biochemistry, sound experimental design, and data science. The Bioinformatics Analyst works closely with Shared Resources cores, especially Genomics and Hutch Data core, to ensure that data quality is high and that users have access to advice and continuing dialog as they review results. Given the large volumes and diverse types of data generated and integrated in Bioinformatics projects, practical applied programming skills are also essential.

At Fred Hutchinson Cancer Center, all employees are expected to demonstrate a commitment to our values of collaboration, compassion, determination, excellence, innovation, integrity, and respect.

Analyze large sequence datasets from diverse workflows including exome capture, RNA-seq, single cell sequencing, ATAC-seq, and CRISPR screens.
• Work with Hutch scientists to refine computational research questions and develop analytical processes that can be applied to these genomic datasets.
• Consult with researchers on sound experimental design.
• Identify appropriate bioinformatics tools to meet the needs of proposed projects.
• Partner with researchers who are developing novel assays to design appropriate processing and analysis workflows.
• Review current literature to identify and adopt software and methodologies, making new analysis capabilities available to the team.
• Provide figures and written sections to document methods and results for manuscripts, presentations, and grant applications.
• Collaborate with colleagues in the Genomics Shared Resource and the Hutch Data Core to ensure the integrity and consistency of primary data, track experimental methods and metadata, define standardized analysis pipelines, and provide support as stakeholders analyze and interpret results.
• Train laboratory members and collaborators on analytic workflows.
• Upload and maintain datasets, workflows, and code (for example GEO, Github).
• Other duties as assigned.

MINIMUM QUALIFICATIONS:

Bioinformatics Analyst I:

• Bachelor's degree in bioinformatics, computational biology, genetics, or related field.
• Some experience in computational analysis of large, complex sequence-based molecular data sets.
• Demonstrated proficiency in R and Python 3 are essential.
• Familiarity with workflow and scheduling software (e.g., Slurm).
• Excellent written and verbal communication skills.

Bioinformatics Analyst II:

• Bachelor's degree in bioinformatics, computational biology, genetics, or related field with at least three years' direct experience in computational analysis of large sequence-based molecular data sets.
• Direct experience must include best-practice germline & somatic variant calling from exome capture data, analysis of bulk RNA-seq data with multiple contrasts, analysis of multimodal single-cell profiling data, epigenetic profiling, gene set enrichment, and integration of data across multiple modalities (e.g., epigenetic profiling and RNA-seq).
• Effective use of shell scripting and significant fluency in R and Python 3 are essential.
• Facility with commonly used Bioconductor packages, ggplot, tidyverse etc.
• Ability to generate and customize common data visualizations (PCA plots, volcano plots, Circos plots, etc).
• Familiarity with workflow and scheduling software (e.g. Slurm).
• Excellent written and verbal communication skills are absolutely required.

PREFERRED QUALIFICATIONS:

Bioinformatics Analyst I:

• A year of more of direct experience in computational analysis of large, complex sequence-based molecular data sets.

Bioinformatics Analyst II:

• Master's degree in bioinformatics, computational biology, genetics, or related field.
• Two+ years of experience in software development, data engineering, data science, or related field with a track record of manipulating, processing, and extracting value from large datasets.
• Experience with single cell transcriptomic analyses and associated pipelines. (e.g. Seurat).
• Direct experience includes whole exome sequencing, and integration of data across multiple modalities (e.g., TCR-seq, CITE-seq, ChIP-seq, ATAC-seq, and CRISPR/Cas9 knockout screens).

Bioinformatics Analyst I: The annual base salary range for this position is from $68,162 to $102,211, and pay offered will be based on experience and qualifications.

Bioinformatics Analyst II: The annual base salary range for this position is from $78,894 to $118,310, and pay offered will be based on experience and qualifications.

Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, tuition reimbursement, paid vacation (12-22 days per year), paid sick leave (12-25 days per year), paid holidays (13 days per year), paid parental leave (up to 4 weeks), and partially paid sabbatical leave (up to 6 months).